Talc poudrage versus talc slurry in the treatment of malignant pleural effusion.

Phase III intergroup study of talc poudrage vs talc slurry sclerosis for malignant pleural effusion.

STUDY OBJECTIVE To demonstrate the efficacy, safety, and appropriate mode of instillation of talc for sclerosis in treatment of malignant pleural effusions (MPEs). DESIGN A prospective, randomized trial was designed to compare thoracoscopy with talc insufflation (TTI) to thoracostomy and talc slurry (TS) for patients with documented MPE. MEASUREMENTS The primary end point was 30-day freedom...

Malignant pleural effusions and the role of talc poudrage and talc slurry: a systematic review and meta-analysis

BACKGROUND Malignant Pleural Effusion (MPE) is common with advanced malignancy. Palliative care with minimal adverse events is the cornerstone of management. Although talc pleurodesis plays an important role in treatment, the best modality of talc application remains controversial.   OBJECTIVE To compare recurrence rates, rates of respiratory and non-respiratory complications between thoracos...

Treatment of recurrent malignant pleural effusion by iodized talc pleurodesis.

Chemical pleurodesis using iodized talc is an effective method of treating symptomatic recurrent malignant pleural effusions. Twenty-three effusions occurring in 21 patients treated by this method are described with two illustrative case reports. The procedure eliminated the need for further chest aspiration in all but one instance. The histological appearances of the pleura at intervals after ...

Malignant pleural effusions and the role of talc poudrage and talc slurry: a systematic review and meta-analysis [version 2; referees: 2 approved, 1 approved with reservations]

Malignant Pleural Effusion (MPE) is common with advanced Background: malignancy. Palliative care with minimal adverse events is the cornerstone of management. Although talc pleurodesis plays an important role in treatment, the best modality of talc application remains controversial. To compare rates of successful pleurodesis, rates of respiratory Objective: and non-respiratory complications bet...

Pleurodesis for malignant pleural effusion: talc, toxicity and where next?